
Unlike the Nikon F5 the Nikon F6 supports matrix metering in "A" and "M" mode with Nikon Ai and AiS manual focus lenses and therefore works with almost any Nikon F-mount lens manufactured since 1977. Therefore it is compatible with the latest generation of Nikon flashes, including the Nikon SB-900. This is the only Nikon 35 mm film camera which features the iTTL OTF flash system. One especially nice feature is the replacement of the removable covers for the PC-sync and 10-pin connectors (which were easily lost) with permanently fixed rubber covers. It general, the camera closely resembles the styling and layout of the Nikon D2-series digital cameras. This may be an asset, as it is much simpler to seal the camera against moisture and dust. Unlike all previous F-series models, it does not feature an interchangeable viewfinder system. The camera body was styled by Giorgetto Giugiaro, who designed all Nikon F bodies since the Nikon F3.


Due to the overwhelming use of digital technology by professional photographers, it is probably the last 35 mm film F-series camera.

The Nikon F6 replaced the Nikon F5 as the professional grade film SLR in 2004.
